Are menopause symptoms getting you down? HRT can relieve menopause symptoms. Hormone replacement therapy can relieve mood swings and irritability, fatigue and sleep problems, hot flashes, and vaginal dryness. HRT helps your body cope with the changes that menopause brings. However, you should discuss the risks and side effects with your doctor. While HRT can reduce your risks of heart disease and osteoporosis, it can also increase your risks of breast and endometrial cancer. As with any drug, you have to weigh the benefits and the risks to determine if it is right for you.